Bisacodyl (Dosing, Interaction, Side Effect, Administration, Etc..)

CLASS:
Laxative, Stimulant

DOSING:

Adult Dose

:
General

Dosage

Information:
This drug has not been found by the US Food and Drug Administration (FDA) to be safe and effective, and the drug product labeling has not been approved by the FDA.

Constipation:
(Tablet)
5 to

15 mg

(usually 10 mg) orally as a

single daily dose

(Enema)
10 mg (one 30-mL bottle) rectally as a single

daily dose

(

Suppository

)

10 mg

(1 suppository) rectally as single daily dose; retain in rectum for 15 to 20 minutes

Preparation of bowel for procedure:
(Enema)
10 mg (one 30-mL bottle) rectally as a single daily dose

Pediatric Dose

:
General Dosage Information:
This drug has not been found by the US Food and Drug Administration (FDA) to be safe and effective, and the drug product labeling has not been approved by the FDA.

Constipation:
(Tablet, 12 years or older)
5 to 15 mg (usually 10 mg) orally as a single daily dose

(Enema, 12 years or older)
10 mg (one 30-mL bottle) rectally as a single daily dose

(Suppository, 12 years or older)
10 mg (1 suppository) rectally as single daily dose; retain in rectum for 15 to 20 minutes

(Suppository, 6 to less than 12 years)

5 mg

(one-half of 1 Suppository) rectally as single daily dose; retain in rectum for 15 to 20 minutes

Preparation of bowel for procedure:
(Enema, 12 years or older)
10 mg (one

30-mL bottle

) rectally as a single daily dose

INDICATIONS:
NON-FDA LABELED INDICATIONS:
Bowel care - Spinal cord injury
Constipation
Gastrointestinal manometry
Neurogenic bowel
Preparation of bowel for procedure

MECHANISM OF ACTION:

Bisacodyl

is hydrolyzed by intestinal brush border enzymes and colonic bacteria to form an active metabolite [bis-(p-hydroxyphenyl) pyridyl-2 methane; (BHPM)] that acts directly on the colonic mucosa to produce colonic peristalsis. The stimulant laxative

effect of bisacodyl

, together with the osmotic effect of the unabsorbed PEG when ingested with a large volume of water, produces watery diarrhea.

ADVERSE EFFECT:
Common:
Gastrointestinal:
Abdominal colic
Abdominal discomfort
Diarrhea
Proctitis With

suppository use

Serious:
Gastrointestinal:
Atony of colon

CONTRAINDICATION:
Appendicitis
Intestinal obstruction
Gastroenteritis

INTERACTION:
Major:
Ascorbic Acid (theoretical)
Licorice (theoretical)
Polyethylene Glycol 3350 (theoretical)
Potassium Chloride (theoretical)
Sodium Ascorbate (theoretical)
Sodium Chloride (theoretical)
Sodium Sulfate (theoretical)

PRECAUTION
Abdominal pain, nausea, vomiting
Rectal bleeding or failure to have bowel movements after administration
Inflammatory bowel disease
Sudden, persistent change in bowel habits
Ulcerated hemorrhoids of rectal fissures

Use for

more than 7 days is not recommended

PREGNANCY CATEGORY:
A (AUS)

BREAST FEEDING:
Infant risk cannot be ruled out.

MONITORING:
Decreased abdominal discomfort and pain
Bowel movement within 15 to 60 min
Reassess if rectal bleeding or no bowel movement after laxative

HOW TO TAKE OR ADMINISTRATION:
Oral:
Take with water.
Do not take within 1 hour after taking an antacid or milk.
Swallow tablets whole, do not chew or crush.

Rectal:

Bisacodyl enemas

and suppositories are

for rectal use

only.

DOSAGE FORM:
Oral Tablet, Delayed Release:
5 MG

Oral Tablet, Enteric Coated:
5 MG

Rectal Suppository

:
10 MG

Rectal Enema:
10 MG/1.25 OZ

TREATMENTS:
MANAGEMENT OF TOXICITY:
Diarrhea:
Rapid correction of fluid and electrolyte deficits with oral or IV fluid therapy and careful monitoring of intake and output are essential. Restrict solid food and maintain high fluid intake until diarrhea resolves. Oral fluid should consist of polyionic hypotonic solution containing appropriate electrolytes.

Hypotension:
Infuse isotonic fluid. If hypotension persists, administer pressors (eg, norepinephrine, dopamine).

TOXICOLOGY:
TOXICITY: The acute minimal toxic or lethal

dose

of these agents is not well established.

SENNA:
CHILDREN:
After the inadvertent ingestion of 10 to 15 Ex-lax (senna-based laxative) chocolate tablets, a child developed superficial partial thickness burns in the perianal area and buttocks within 10 minutes of experiencing diarrhea. A man developed abdominal pain, jaundice, fatigue, and elevated liver enzymes following the daily

use of an herbal laxative

containing sennoside (15 to

30 mg

/day) for over 3 months. Liver enzymes gradually improved and were within normal limits one month after sennoside was discontinued.

PATIENT COUNSELING OR CLINICAL TEACHING:
This drug may cause diarrhea or abdominal pain, discomfort, and cramping. The suppositories may cause proctitis.
Patient should expect to have a bowel movement within 15 to 60 min

after suppository administration

.
Instruct patient to report rectal bleeding or failure to have bowel movements within 12 h after taking oral formulation.
Patient should not take

bisacodyl tablets

within 1 h of antacids, milk, or milk products.
Patient should not

take bisacodyl

for more than 7 days, unless approved by healthcare professional.




Disclaimer:
For the Registered Medical Practitioner Only. We are not recommended for self medication. self medication is may harmful for health. We are only information about medicine.