Sertaconazole (Dosing, Interaction, Side Effect, Administration, Etc..)

DRUG CLASS:
Antifungal
Imidazole

DOSING:

Adult Dose

:
Seborrheic dermatitis:
Apply

2% cream

to affected areas twice daily for 4 weeks (

study dose

).

Tinea pedis; Interdigital:
Apply cream topically twice daily for 4 weeks.

Pediatric Dose

:
Seborrheic dermatitis:
(4 years or older)
Apply

2% cream

to affected areas twice daily for 4 weeks (

study dose

).

Tinea pedis; Interdigital:
(12 years or older)

Apply cream

topically twice daily for 4 weeks.

INDICATIONS:
FDA-LABELED INDICATIONS:
Tinea pedis
Interdigital

NON-FDA LABELED INDICATIONS:
Candidal vulvovaginitis
Seborrheic dermatitis
Tinea

MECHANISM OF ACTION:

Sertaconazole nitrate

is an imidazole antifungal agent that has no precise

mechanism of action

; although it is believed to exert its effect by blocking the cytochrome P450-dependent synthesis of ergosterol; which is a vital element of fungal cell membrane. This action reduces ergosterol which causes leakage of important cytoplasmic constituents from the cell and subsequent fungal cell injury

ADVERSE EFFECT:
Common:
Dermatologic:
Application site Reaction Contact Dermatitis.

CONTRAINDICATION:
Specific Contraindications have not been determined

PRECAUTION:
Azole antifungal sensitivity; history; cross-sensitivity may occur; discontinuation may be required
Irritation may occur; if suspected; discontinue therapy; further treatment of irritation may be required

PREGNANCY CATEGORY:
C (FDA)

BREAST FEEDING:
Infant risk cannot be ruled out

MONITORING:
Symptomatic improvement
Local reactions; including contact dermatitis; dry skin; burning; tenderness; hyperpigmentation; erythema; desquamation; vesiculation; and pruritus

HOW TO TAKE OR ADMINISTRATION:
Topical:
Dry the affected area thoroughly, as needed, before application
Apply to affected areas and the immediate surrounding healthy skin
Avoid occlusive dressings unless directed by the physician
Avoid contact with eyes, nose, mouth and other mucous membrane

DOSAGE FORM:
Topical Cream: 2%

TOXICOLOGY:
A minimum

toxic dose

has not been established, and significant toxicity is not expected after an

overdose

. Ingestion of even large quantities should produce only minor GI symptoms (e.g.; nausea; vomiting; and diarrhea).

TREATMENTS:
MANAGEMENT OF MILD TO MODERATE TOXICITY:
Treatment is symptomatic and supportive. Toxicity due to these agents is negligible.

MANAGEMENT OF SEVERE TOXICITY:
Treatment is symptomatic and supportive. Significant toxicity is not expected after an overdose. Correct any significant fluid and/or electrolyte abnormalities in patients with severe diarrhea and/or vomiting. In patients with acute allergic reaction; oxygen therapy; bronchodilators; diphenhydramine; corticosteroids; vasopressors and epinephrine may be required.

PATIENT COUNSELING OR CLINICAL TEACHING:
This drug may cause dermatitis and dry skin
Patient should contact healthcare professional if affected skin does not improve or gets worse during drug therapy
Advise patient to apply drug to clean; dry affected skin and surrounding healthy skin. Patient should avoid drug contact with eyes; nose; mouth; and broken skin areas. Patient should not apply occlusive dressings or skin care products to treated skin




Disclaimer:
For the Registered Medical Practitioner Only. We are not recommended for self medication. self medication is may harmful for health. We are only information about medicine.